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Human papillomavirus infection in recurrent upper respiratory tract papillomatosis



Human papillomavirus infection in recurrent upper respiratory tract papillomatosis



Archiv fuer Geschwulstforschung 60(6): 429-434



Tissue samples from 10 patients with recurrent respiratory tract papillomatosis were analyzed for the presence of Human Papillomavirus (HPV) sequences by DNA hybridization techniques. Eight patients were affected by papillomatosis of the larynx and 2 of the nasal septum. DNA hybridization analysis showed that all the patients were infected by HPV types 6 or 11. In a patient who had a recurrence of the disease at tracheal and bronchial level, HPV 11 sequences were found in a bronchial squamous intraepithelial neoplasia of grade III, in a synchronous tracheal papillomatous lesion and in the normal tissue surrounding the papilloma.

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