+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Improved control of atrial fibrillation with combined pindolol and digoxin therapy



Improved control of atrial fibrillation with combined pindolol and digoxin therapy



European Heart Journal 10(1): 83-90



This study has compared the effect on heart rate control of the addition of pindolol 15 mg bd or verapamil 40 mg tds to maintenance digoxin therapy in 12 patients with chronic atrial fibrillation. The study was performed in a randomized cross-over fashion. Treatment effects were assessed by 24-h ambulatory electrocardiography and symptomatic improvement by symptom scores. The results show that the combination of pindolol and digoxin provides better control of atrial fibrillation. With an attenuation of daytime tachycardia, prevention of nocturnal bradycardia and reduction in the length of nocturnal pauses in rhythm. Overall heart rate variability was significantly less with digoxin and pindolol (523 beats min-1 h-1) than with digoxin and verapamil (745 beats min-1 h-1). We conclude that, in the dosages employed, combined digoxin and pindolol therapy is superior to either digoxin and verapamil in combination or digoxin alone for the treatment of atrial fibrillation.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 007434890

Download citation: RISBibTeXText

PMID: 2702970


Related references

Value of serum digoxin concentration measurement in the control of digoxin therapy in atrial fibrillation. Israel Journal of Medical Sciences 15(6): 490-493, 1979

Comparative effects of the combination of digoxin and dl-sotalol therapy versus digoxin monotherapy for control of ventricular response in chronic atrial fibrillation. American Heart Journal. 127(3): 572-577, 1994

Pindolol, not verapamil, in combination with digoxin is the treatment of choice in chronic atrial fibrillation. Clinical Science 76(2): 229-230, 1989

Cardiac findings in atrial fibrillation and sinus rhythm. Should long-term digoxin therapy be withdrawn in atrial fibrillation?. Ugeskrift for Laeger 145(26): 2025-2026, 1983

Diltiazem alone in chronic atrial fibrillation efficacy to control exercise induced tachycardia despite digoxin therapy. European Heart Journal 10(ABSTR SUPPL): 155, 1989

Comparative effects of nadolol-digoxin combination therapy and digoxin monotherapy for chronic atrial fibrillation. American Journal of Cardiology 60(6): 39d-45d, 1987

Pindolol Improves Control of Atrial Fibrillation. Clinical Science 73(S17): 8p.3-8p, 1987

Combined use of esmolol and digoxin in the acute treatment of atrial fibrillation or flutter. American Heart Journal. 126(2): 368-374, 1993

Study of combined use of digoxin and esmolol in atrial fibrillation with rapid heart rate. Clinical Research 39(4): 825A, 1991

Atrial fibrillation: Rate control and digoxin. Bmj 335(7631): 1169-1170, 2007

Clinical decision analysis modeling: short-term control of ventricular response rate in atrial fibrillation or atrial flutter-digoxin versus diltiazem. PharmacoTherapy 14(4): 446-451, 1994

Digoxin therapy for atrial fibrillation in the twenty-first century. American Journal of Therapeutics 21(5): 325-326, 2015

Comparison of medigoxin and digoxin in the control of atrial fibrillation. British Journal of Clinical Pharmacology 8(1): 53-58, 1979

Progression of atrial fibrillation in the REgistry on Cardiac rhythm disORDers assessing the control of Atrial Fibrillation cohort: clinical correlates and the effect of rhythm-control therapy. American Heart Journal 163(5): 887-893, 2012

The randomized Easton atrial fibrillation trial of procainamide vs digoxin in recent onset atrial fibrillation. Journal of Investigative Medicine 43(SUPPL 3): 510A, 1995