In vitro antimycobacterial activities of new quinolones ofloxacin enoxacin and ciprofloxacin

Kawahara S.; Kamisaka K.; Tada A.; Et Al

Japanese Journal of Chest Diseases 49(11): 954-959


Accession: 007438017

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In vitro activities of three new quinolones (ofloxacin (OFLX), enoxacin (ENX) and ciprofloxacin (CPFX)) against mycobacteria species were studied, and the following results were obtained. 1) OFLX showed a strong activity against M. tuberculosis, M. kansasii and M. fortuitum. 2) The activities of OFLX and CPFX against M. tuberculosis were almost equally potent, but the activity of ENX was much lower than those of the former two agents. 3) All agents showed low activities against M. avium complex and were regarded as ineffective in practical use. 4) The activity of CPFX against M. kansasii was much lower than that of OFLX. 5) CPFX didn't show any activity against OFLX-resistant M. tuberculosis strains, suggesting the presence of cross-resistance between OFLX and CPFX.