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In vitro effect of praziquantel mebendazole and oxfendazole on echinococcus granulosus protoscolices


In vitro effect of praziquantel mebendazole and oxfendazole on echinococcus granulosus protoscolices



Revista Iberica de Parasitologia 49(1): 77-84



ISSN/ISBN: 0034-9623

Echinococcus granulosus protoscoleces were incubated in media to which 0.1, 1, 10, 20, 50, or 100 .mu.g/ml of praziquantel, mebendazole or oxfendazole were added. Praziquantel proved to be the fastest-acting drug, producing death after 48 hours at all the test concentrations. The loss of hooks and microtriches in the apical region and tegumental damage in the protoscoleces could be observed at 45 minutes after drug administration. Mebendazole and oxfendazole action was much slower, provoking vesicularization and microthrix fusion and loss, and finally, death of the parasite after five days.

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Accession: 007438718

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