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In vitro release kinetics of timolol and timolol maleate from polyethylcyanoacrylate nanoparticles ii. nanoparticles manufactured with timolol maleate using different surfactants and organic solvents



In vitro release kinetics of timolol and timolol maleate from polyethylcyanoacrylate nanoparticles ii. nanoparticles manufactured with timolol maleate using different surfactants and organic solvents



Acta Pharmaceutica Fennica 101(2): 57-63



In this study the manufacturing of polyethylcyanoacrylate nanoparticles with timolol maleate by anionic polymerization was investigated. Different non-ionic surfactants and organic solvents were used for the solubilization of timolol maleate in order to polymerize these solubilized solutions with ethylcyanoacrylate. The effect of both, the drug and water concentration of the micelles on the in vitro drug release rate of the nanoparticles was studied. It was shown that the solubilization and polymerization were most successful using polyoxyethylated non-ionic surfactants and n-alkanes as solvents for solubilization. About 90 per cent of the initial timolol maleate concentration could be solubilized into the nanoparticles. The incorporation was neither affected by the drug concentration nor by the water content of the micelles. With this system a drug release rate of zero-order could not been achieved: the release of timolol maleate was rather controlled by its diffusion through the matrix following the cube root equation.

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