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Influence of antidepressants on some effects of benzodiazepines diazepam and nitrazepam

Influence of antidepressants on some effects of benzodiazepines diazepam and nitrazepam

Farmakologiya i Toksikologiya 51(4): 16-19

Incazane and pyrazidol given to mice in certain doses were found to reduce the sedative action of diazepam without decreasing its anxiolytic effect but at the same time enhancing the anticonvulsive one. Imipramine diminishes the hypolocomotor action of diazepam and also its anxiolytic effect and exerts no influence on the anticonvulsive effect. All studied antidepressants diminish the hypnotic action on nitrazepam in mice but only incazane and pyrazidol decrease the sedative-hypnotic effect of nitrazepam in rats. In connection with the lack of the influence on the anxiolytic effect, incazane and pyrazidol may be used to decrease the sedative side effects of benzodiazepines.

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