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Inhibition of adenylate cyclase by tetraplatin



Inhibition of adenylate cyclase by tetraplatin



Anti-Cancer Drugs 2(3): 267-268



In the investigation of effects of platinum-containing compounds on dopamine (DA)-activated adenylate cyclase system, tetraplatin and cisplatin were found to suppress the increase of enzyme activity by various activators. However, tetraplatin was a much more potent inhibitor than cisplatin, with its I50 values being 1/25, 1/45, and 1/130 that of cisplatin in the presence of DA/Gpp(NH)p, NaF/AlCl3, and forskolin/Gpp(NH)p respectively.

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Accession: 007463104

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PMID: 1802021

DOI: 10.1097/00001813-199106000-00007



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