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Inhibition of lipid membrane self oscillation by addition of protein having its membrane penetrating property






Jikeikai Medical Journal 37(3): 311-324

Inhibition of lipid membrane self oscillation by addition of protein having its membrane penetrating property

Self-oscillation of electrical potential across a thin-film of L-.alpha.-dioleoyllecithin deposited onto a fine-pore membrane filter according to the Langmuir-Blodgett film technique, which was imposed between equimolar aqueous solutions of NaCl and KCl, was found to be inhibited by the addition of staphylococcal .alpha.-toxin into one of the aqueous solutions. Since it has been reconized that the monomeric toxin molecules penetrate into lipid membranes to form a transmembrane ring-shaped structure (hexamer of the toxin molecules), the observed inhibition of the Na+/K+ concentration gradient-induced electric oscillation by the toxin addition has been tentatively considered as a result of the penetration and then micropore-bearing hexamer formation of the toxin in the lipid bilayer.

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Accession: 007464800



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