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Interleukin 1 beta and tumor necrosis factor alpha stimulate the release of gonadotropin releasing hormone and interleukin 6 by primary cultured rat hypothalamic cells



Interleukin 1 beta and tumor necrosis factor alpha stimulate the release of gonadotropin releasing hormone and interleukin 6 by primary cultured rat hypothalamic cells



Acta Endocrinologica 123(4): 476-480



The abilities of recombinant human interleukin 1.beta. and tumour necrosis factor .alpha. to induce release of GnRH and interleukin 6 from primary culture of rat hypothalamic cells were examined. The effect of estradiol on the release of interleukin 6 by these cells was also tested. Both interleukin 1.beta. and tumour necrosis factor .alpha. caused significant stimulation of GnRH secretion from the hypothalamic cells within 5 min. The hypothalamic cells secreted interleukin 6 spontaneously, and their secretion over 24 h was stimulated dose-dependently by interleukin 1.beta., tumour necrosis factor .alpha. and estradiol. These results suggest that interleukin 1.beta. and tumour necrosis factor .alpha. stimulate the secretions of GnRH and interleukin 6 in the hypothalamus, and that these cytokines may be involved in the mechanism of GnRH secretion in the hypothalamus.

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Accession: 007476423

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PMID: 2239094


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