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Interleukin 2 receptor beta chain gene generation of three receptor forms by cloned human alpha and beta chain complementary dna



Interleukin 2 receptor beta chain gene generation of three receptor forms by cloned human alpha and beta chain complementary dna



Science 244(4904): 551-556



Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor .alpha. (IL-2R.alpha., p55) chain and the newly identified IL-2 receptor .beta. (IL-2R.beta., p70-75) chain. The cDNA encoding the human IL-2R.beta. chain has now been isolated. The overall primary structure of the IL-2R.beta. chain shows no apparent homology to other known receptors. Unlike the IL-2R.alpha. chain, the IL-2R.beta. chain has a large cytoplasmic region in which a functional domain (or domains) mediating an intracellular signal transduction pathway (or pathways) may be embodied. The cDNA-encoded .beta. chain binds and internalizes IL-2 when expressed on T lymphoid cells but not fibroblast cells. Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2R.alpha. chain cDNA.

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Accession: 007476904

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Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Science 244(4904): 551-556, 1989

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