Iodine 125 endothelin 1 binding to brain and cardiac membranes from normotensive and spontaneously hypertensive rats

G.X.H.; Casley, D.J.; Cincotta, M.; Nayler, W.G.

European Journal of Pharmacology 177(3): 205-210


ISSN/ISBN: 0014-2999
Accession: 007487859

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125I-labelled endothelin-1 was used to identify specific high affinity endothelin-1 binding sites in left ventricular and brain membranes harvested from female age-matched normotensive Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Relative to results obtained for brain membranes from normotensive rats, brain membranes from hypertensive rats exhibited an increase in 125I-endothelin-1 binding site density (P < 0.02). In left ventricular membranes from the hypertensive rats 125I-endothelin-1 binding site density was reduced (P < 0.02), relative to the density in ventricular membranes of normotensive rats. These rats indicate that hypertension may have an organ specific effect on 125I-endothelin-1 binding site density.