+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Iron stores in essential thrombocythemia a study of 26 patients

Iron stores in essential thrombocythemia a study of 26 patients

Blut 58(6): 291-294

The iron status of 26 patients with eseential thrombocythaemia (ET) was evaluated at diagnosis by means of bone marrow iron and blood studies, including serum ferritin determination. Nine patients were males, 17 females, and the mean age was 53 years (range 7-81). A decreased or absent iron level by semiquantitative estimation on bone marrow smears was observed in 77% of patients, and 81% had a low sideroblast score. Such a marrow pattern of iron depletion was equally distributed between both sexes. Contrasting with this, normal Hb, MCV, serum iron and serum ferritin were registered in the majority of cases. According to these results, absent or decreased marrow iron would be a common feature in ET, generally not reflecting true iron deficiency, as it occurs in the remaining chronic myeloproliferative disorders. Thus, in patients in whom ET is suspected, the diagnostic criterion of ruling our iron deficiency would be better served by serum ferritin measurement than by bone marrow iron estimation.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 007489161

Download citation: RISBibTeXText

PMID: 2736309

Related references

Essential differences in clinical and bone marrow features in BCR/ABL-positive thrombocythemia compared to thrombocythemia in the BCR/ABL-negative myeloproliferative neoplasms essential thrombocythemia and polycythemia vera. Acta Haematologica 133(1): 52-55, 2015

Body iron stores and iron restoration rate in Japanese patients with chronic hepatitis C as measured during therapeutic iron removal revealed neither increased body iron stores nor effects of C282Y and H63D mutations on iron indices. Nagoya Journal of Medical Science 64(1-2): 51-57, 2001

Coexistence of Essential Thrombocythemia, Iron-Refractory Iron Deficiency Anemia and Renal Cell Carcinoma. Hematology Reports 8(1): 6235, 2016

Intravenous iron sucrose is superior to oral iron sulphate for correcting anaemia and restoring iron stores in IBD patients: A randomized, controlled, evaluator-blind, multicentre study. Scandinavian Journal of Gastroenterology 44(7): 838-845, 2009

Essential thrombocythemia: a retrospective study on the clinical course of 100 patients. Haematologica 75(6): 537-540, 1990

Thrombosis and survival in essential thrombocythemia: a regional study of 1,144 patients. American Journal of Hematology 89(5): 542-546, 2014

Phase II study of pegylated intron in patients with essential thrombocythemia. Blood 98(11 Part 1): 629a-630a, 2001

Efficacy trial of pipobroman in essential thrombocythemia: a study of 24 patients. Cancer Treatment Reports 68(11): 1339-1342, 1984

Essential hemorrhagic thrombocythemia a clinical and laboratory study of 13 patients. Thrombosis & Haemostasis 50(1): 216, 1983

Pilot study of pegylated interferon-alpha 2b in patients with essential thrombocythemia. Cancer ChemoTherapy and Pharmacology 51(1): 81-86, 2003

Thrombotic and hemorrhagic complications in essential thrombocythemia. A retrospective study of 103 patients. Cancer 67(11): 2926-2930, 1991

Proposal for revised diagnostic criteria of essential thrombocythemia and polycythemia vera by the Thrombocythemia Vera Study Group. Seminars in Thrombosis and Hemostasis 23(4): 339-347, 1997

The effectiveness of anagrelide treatment in patients with Ph negative myeloproliferative diseases: influence on the incidence of thrombosis in the data from the Registry of patients with essential thrombocythemia and thrombocythemia associated with other myeloproliferative diseases treated with Thromboreductin® to the end of 2012. Vnitrni Lekarstvi 59(6): 516-531, 2013

Clinical correlates of megakaryocyte c-Mpl expression in essential thrombocythemia A clinicopathologic study of 169 patients. Blood 96(11 Part 1): 742a, 2000