Lactate dehydrogenase activity and its isoenzyme spectrum in the human pancreas in the prenatal period
Davidenko, L.M.; Zaĭchenko, I.V.; Kononenko, V.Ia.; Popova, L.I.
Fiziologicheskii Zhurnal 35(4): 106-109
ISSN/ISBN: 0201-8489 PMID: 2792432 Accession: 007504085
Lactate dehydrogenase (LDG) activity and the character of its isoenzyme distribution in pancreas of the human embryos and feti of the 5th-13th-week development were studied. It is shown that LDG-activity was rather high already in early periods of the embryonic development, peaks of the enzymic activity were observed after 7-8 and 12-13 weeks. The isoenzymic LDG spectrum was characterized by the presence of four isoenzymes: LDG1, LDG2, LDG3, LDG5. Isoenzyme LDG4 was absent in the human pancreas in all the studied periods of embryonic development. The data obtained evidence for intensity of the glycolysis processes at LDG-reaction level in the prenatal ontogenesis period and they reflect most probably the processes of development and differentiation of cellular populations in the given organ.