+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Left ventricular hypertrophy independent of hypertension in patients with obstructive sleep apnea



Left ventricular hypertrophy independent of hypertension in patients with obstructive sleep apnea



Journal of Hypertension 8(10): 941-946



To evaluate cardiac structure and function as well as blood pressure in the obstructive sleep apnoea syndrome (OSAS), we investigated 61 male patients and 61 male controls with M-mode and two-dimensional echocardiography. All patients had a history of hibitual snoring and a diagnosed light to severe OSAS by previous investigations of nocturnal oxygen saturation status. No subject in the control group had a history of OSAS or hypertension. Body weight was higher in the OSAS patients than in the controls (P < 0.001). Fifty per cent (31 out of 61) of the OSAS patients had systemic hypertension; 17 of these 31 were on pharmacological antihypertensive treatment. Neither the systolic nor the diastolic blood pressures were found to correlate to the severity of the OSAS (desaturation index). The heart rate was higher at rest in the OSAS patients with or without systemic hypertension compared to the controls with or without a blood pressure level above 165/95 mmHHg (P < 0.05 and P < 0.01, respectively). Left ventricular (LV) internal dimensions as assessed by echocardiography did not differ between the two groups, while the interventricular septum and the LV posterior wall were thicker in the OSAS group. Thus, the LV mass and the LV mass index were significantly higher among the OSAS patients (P < 0.001 and P < 0.001). The LV mass index was approximately 15% higher among the 30 normotensive OSAS patients with no history of cardiac disease compared with the normotensive controls (P < 0.05). Patients and controls without antihypertensive treatment, matched by weight (n = 20), had different LV mass (259 .+-. 12 versus 221 .+-. 8 g, P = 0.01), despite there being no difference in the daytime blood pressure. The ejection fraction and the left atrial dimension did not differ between patients and controls. Measures of LV structure or function were not correlated to the severity of the OSAS as depicted by desaturation index or minimal nocturnal oxygen saturation during nocturnal investigations. Thus, both systemic hypertension and LV hypertrophy seem to be common phenomena in OSAS. We did not find the severity of OSAS to be predictive of systemic hypertension or LV structural changes. Also, OSAS patients without hypertension had LV hypertrophy, the development or which may be partly due to other pathophysiological mechanisms.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 007509119

Download citation: RISBibTeXText

PMID: 2174947


Related references

Left ventricular hypertrophy independent of hypertension in patients with obstructive sleep apnoea. Journal of Hypertension 8(10): 941-946, 1990

Deletion Polymorphism of Angiotensin Converting Enzyme Gene is Associated with Left Ventricular Hypertrophy in Uighur Hypertension-Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Patients. Medical Science Monitor 25: 3390-3396, 2019

Nocturnal Intermittent Hypoxia Is Associated With Left Ventricular Hypertrophy in Middle-Aged Men With Hypertension and Obstructive Sleep Apnea. American Journal of Hypertension 29(3): 372-378, 2016

Left ventricular hypertrophy in obstructive sleep apnea patients. European Heart Journal 10(ABSTR SUPPL): 203, 1989

Independent association of obstructive sleep apnea with left ventricular geometry and systolic function in resistant hypertension: the RESIST-POL study. Sleep Medicine 15(11): 1302-1308, 2015

Left ventricular geometry in patients with obstructive sleep apnea coexisting with treated systemic hypertension. Respiration; International Review of Thoracic Diseases 74(2): 176-183, 2006

Left ventricular hypertrophy and abnormal ventricular geometry in children and adolescents with obstructive sleep apnea. American Journal of Respiratory and Critical Care Medicine 165(10): 1395-1399, 2002

Integrated area of desaturation, a new index of sleep-disordered breathing, is associated with left ventricular hypertrophy among hypertensive men with obstructive sleep apnea. European Heart Journal 34(Suppl 1): P2372-P2372, 2013

Prevalence of left ventricular hypertrophy in persons with and without obstructive sleep apnea. Cardiology in Review 14(4): 170-172, 2006

Sleep apnea-associated hypertension and reversible left ventricular hypertrophy. Journal of Pediatrics 111(2): 253-255, 1987

Investigation of relationship between obstructive sleep apnea hypopnea syndrome and left ventricular hypertrophy. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 27(15): 830-1, 835, 2014

Echocardiographic left ventricular hypertrophy and response to exercise in obstructive sleep apnea syndrome. European Respiratory Journal Supplement 10(25): 280S, Sept, 1997

Severe obstructive sleep apnea increases left atrial volume independent of left ventricular diastolic impairment. European Heart Journal 34(Suppl 1): P1119-P1119, 2013

A possible role of visceral fat-related inflammation in linking obstructive sleep apnea to left ventricular hypertrophy. Hypertension 49(4): E23; Author Reply E24-E23; Author Reply E24, 2007

Effects of nasal continuous positive airway pressure on left ventricular concentric hypertrophy in obstructive sleep apnea syndrome. Internal Medicine 51(20): 2863-2868, 2013