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Levonorgestrel ethynylestradiol development toxicity study with behavioral and reproductive assessment of the offspring seg ii rat



Levonorgestrel ethynylestradiol development toxicity study with behavioral and reproductive assessment of the offspring seg ii rat



Oyo Yakuri 42(4): 327-340



Levonorgestrel/ethinyl estradiol, a combination progestin/estrogen oral contraceptive, was administered orally by gavage to mated female rats during organogenesis to evaluate its potential developmental toxicity (embryo/fetal toxicity and teratogenicity). Postnatal survival, growth, reflex and morphological development, learning and memory capability, and reproductive peformance of the offspring were also evaluated. In dams, drug-related effects occured in the 16.0 and 80.0 mcg/kg groups including significant decrease in gestation body weight gains and food consumption during the treatment period (GD 7-17). Although significant increase in water consumption occurred in all drug treated groups during the last third of the treatment period (GD 14-17), these differences were not biologically important because the values were comparable to those for the untreated-control group. In pups, no drug-related effects were observed for the F1 or F2 rats.

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Accession: 007511256

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