EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Maximal oxygen uptake in severe aortic regurgitation a different view of left ventricular function


American Heart Journal 120(4): 902-909
Maximal oxygen uptake in severe aortic regurgitation a different view of left ventricular function
Respiratory gas exchange was used to assess left ventricular (LV) function in 22 patients with severe aortic regurgitation (19 men and three women, aged 18 and 70 years, mean 49 years). Anaerobic threshold and symptom-limited maximal oxygen consumption (VO2 max) were measured during treadmill exercise, and the results were compared with conventional echocardiographic and radionuclide indices of LV systolic function. The results were considered with respect to the patients' New York Heart Association functional class. Both rest and exercise LV ejection fractions were variable, but the mean results were similar in all classes. The echocardiographic indices of LV cavity dimensions, fractional shortening, radius/thickenss ratio, and systolic wall stress also showed a wide range but with similar mean results in each class. In contrast, VO2 max and anaerobic threshold showed a relationship to functional class. VO2 max was 32.4 .+-. 3.4 ml/kg/min in age-matched control subjects; in the patients it was 27.9 .+-. 4.7 in class I, 24.7 .+-. 5.7 in class II, and 14.2 .+-. 2 in the combined class III/IV. Results in patients in classes I and II were similar, but both groups were significantly different from control subjects (p < 0.05) and from patients in class III/IV (p < 0.01). About half of the patients with moderate LV dysfunction (judged by reduced VO2 max) were asymptomatic, and LV function was impaired in 4 of 10 patients in class I. Thus, unlike conventional indices of LV function, VO2 max appeared capable of distinguishing patients with moderate-to-severe LV dysfunction from those with little or no LV dysfunction. Measurement of respiratory gas exchange appears to be a valid and useful supplementary means of assessing LV function in severe aortic regurgitation. Further long-term evaluation is required.

Accession: 007536790

PMID: 2220544

DOI: 10.1016/0002-8703(90)90208-f

Download PDF Full Text: Maximal oxygen uptake in severe aortic regurgitation a different view of left ventricular function



Related references

The use of maximal oxygen uptake capacity to assess left ventricular function in severe aortic regurgitation. Clinical Science (London) 70(SUPPL 13): 35P-36P, 1986

Long term survival of left ventricular function after aortic valve replacement in cases with aortic regurgitation left ventricular volume wall thickness and left ventricular mass. Journal of the Japanese Association for Thoracic Surgery 29(2): 259-264, 1981

The long-term survival left ventricular function after aortic valve replacement in the cases with aortic regurgitation; especially on the left ventricular volume, wall thickness and left ventricular mass. Nihon Kyobu Geka Gakkai 29(2): 259-264, 1981

Outcomes after aortic valve replacement in patients with severe aortic regurgitation and markedly reduced left ventricular function. Circulation 106(21): 2687-2693, 2002

Effects of valve replacement on left ventricular function in patients with aortic regurgitation and severe ventricular disease. Journal of Heart Valve Disease 13(5): 722-728, 2004

Assessment of left ventricular function in severe aortic regurgitation. Circulation 54(6): 975-979, 1976

Relationships between left ventricular morphology, diastolic function and oxygen carrying capacity and maximal oxygen uptake in children. International Journal of Sports Medicine 26(2): 122-127, 2005

Relation between myocardial beta-adrenergic receptor and left ventricular function in patients with left ventricular volume overload due to chronic mitral regurgitation with or without aortic regurgitation. American Journal of Cardiology 68(1): 81-84, 1991

Aortic root dilatation as a cause of isolated, severe aortic regurgitation. Prevalence, clinical and echocardiographic patterns, and relation to left ventricular hypertrophy and function. Annals of Internal Medicine 106(6): 800-807, 1987

Relationship between maximal oxygen uptake and left ventricular function in exercise. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology 44(1): 44-49, 1978