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Measurement of specific surface area of pharmaceutical powders by the bet method effect of drying time and drying temperature


Measurement of specific surface area of pharmaceutical powders by the bet method effect of drying time and drying temperature



Acta Pharmaceutica Nordica 3(1): 15-18



ISSN/ISBN: 1100-1801

The effect of drying temperature (40, 80 and 120.degree.C) and drying time (2, 6 and 24 h) on the specific surface area of theophylline, potassium chloride and silicone dioxide was studied. The specific surface areas were measured by the BET method. The samples were dried in a vacuum oven. The temperature and the pressure of the oven were measured continuously during drying. The result showed that the drying temperature affected the specific surface area of all samples studied, although the effect was not simple. The specific surface area was only slightly affected when drying was performed at low temperatures. When a high drying temperature (120.degree.C) and a long drying time (24 h) were used, the specific surface areas of the samples seemed to decrease systematically. It is concluded that when the specific surface area of pharmaceutical materials is measured by the BET method, it is necessary to describe the drying conditions in detail.

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