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Molecular pathogenesis of equine coital exanthema: identification and expression of infected cell polypeptides at the restricted temperature during equine herpesvirus 3 infection



Molecular pathogenesis of equine coital exanthema: identification and expression of infected cell polypeptides at the restricted temperature during equine herpesvirus 3 infection



Veterinary Microbiology 18(3-4): 363-371



Equine herpesvirus 3 (EHV-3)-infected equine cells display a kinetics of infected cell polypeptide (ICP) synthesis at 34.degree. C that is typical of coordinate cascade gene regulation of herpesviruses. In contrast, when infected cell cultures are incubated at the restricted temperature of 39.degree. C, the shift from early (.beta.) gene expression to late (.gamma.) gene expression is perturbed, i.e., there is an accumulation of early (.beta.) gene products and a decrease in, or absence of, late (.gamma.) gene products. Some of the affected late (.gamma.) gene products may be glycoproteins since these ICPs co-migrated with radiolabeled bands from infected cells incubated with [3H] glucosamine, separated by polyacrylamide gel electrophoresis. These findings are consistent with previous findings (Jacob, 1986), indicating that the growth restriction is in a late viral function(s) and possibly involves envelopment of nucleocapsids into infectious virions.

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Accession: 007564786

Download citation: RISBibTeXText

PMID: 2852875

DOI: 10.1016/0378-1135(88)90101-0


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