EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Naloxone fails to alter local cerebral glucose utilization in the rat



Naloxone fails to alter local cerebral glucose utilization in the rat



Pharmacology Biochemistry & Behavior 31(2): 481-486



The autoradiographic, 2-deoxy-D-[1-14C]glucose ([14C]DG) method was used to map the effects of intravenous (IV) naloxone (1.0, 10.0, and 20.0 mg/kg) on local cerebral glucose utilization (LCGU), an index of local brain function. Naloxone injected 5 min before [14C]DG did not alter LCGU in any of the fifty-six brain regions examined. Our findings suggest that acute naloxone at these doses does not significantly affect cerebral metabolism.

(PDF emailed within 0-6 h: $19.90)

Accession: 007582177

Download citation: RISBibTeXText

PMID: 3244723

DOI: 10.1016/0091-3057(88)90377-2



Related references

Localized effects of naloxone on local cerebral glucose utilization in rat cerebral nuclei with Met-enkephalinergic neurons. Japanese Journal of Pharmacology 36(3): 339-348, 1984

Localized effects of naloxone on local cerebral glucose utilization in rat cerebral nuclei with methionine enkephalinergic neurons. Japanese Journal of Pharmacology 36(3): 339-348, 1984

Naloxone selectively increases local cerebral glucose utilization in rats. Federation Proceedings 43(3): ABSTRACT 2669, 1984

Quantitation of local cerebral glucose utilization during opioid dependence and naloxone precipitated withdrawal. Society For Neuroscience Abstracts: 1151, 1985

Mapping local cerebral functional activity by measurement of local cerebral glucose utilization with radioactive 2 deoxy glucose. Electroencephalography & Clinical Neurophysiology 53(5): 51P, 1982

The relationship between local cerebral glucose utilization and local cerebral blood flow during the action of gamma hydroxy butyrate. Pfluegers Archiv European Journal Of Physiologyuppl: R10, 1982

Increase in local cerebral glucose utilization and decrease in local cerebral blood flow in rat ca1 subfield 7 days after ischemia. Naunyn-Schmiedeberg's Archives of Pharmacology 341(SUPPL): R103, 1990

Influence of gamma hydroxybutyrate on the relationship between local cerebral glucose utilization and local cerebral blood flow in the rat brain. Journal of Cerebral Blood Flow & Metabolism 5(1): 58-64, 1985

Dose dependent effects of dihydroergocristine on local cerebral blood flow and local cerebral glucose utilization in the conscious rat. Naunyn-Schmiedeberg's Archives of Pharmacology 329(SUPPL): R89, 1985

Effects of the indirect dopaminomimetic diethylpemoline on local cerebral glucose utilization and local cerebral blood flow in the conscious rat. European Journal of Pharmacology 125(3): 437-448, 1986

Increased local cerebral glucose utilization and decreased local cerebral blood flow in rat ca1 hippocampal subfield 7 days after ischemia. PZ (Pharmazeutische Zeitung) Wissenschaft 135(1): 23-28, 1990

The effects of n methyl d aspartate nmda receptor blockade upon local cerebral glucose utilization and local cerebral blood flow. Society for Neuroscience Abstracts 13(2): 1031, 1987

Effect of apo morphine on the relationship between local cerebral glucose utilization and local cerebral blood flow with an appendix on its statistical analysis. Journal of Cerebral Blood Flow & Metabolism 2(4): 487-499, 1982

Stimulatory effects of lisuride on local cerebral blood flow and local cerebral glucose utilization in rats. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 91(6): 341-349, 1988

Coupling of local cerebral blood flow to local cerebral glucose utilization during isoflurane and sevoflurane anesthesia. Anesthesiology 91(3): 889-891, 1999