Nucleotide sequence of the gene of kappa immunoglobulin light chain produced by the hybridoma ptf 02 and some elements of transcription regulation

Adzhalov, V.A.; Shakhmuradov, I.A.

Izvestiya Akademii Nauk Azerbaidzhanskoi SSR Seriya Biologicheskikh Nauk 5: 119-125


Accession: 007604936

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Nucleotide sequence was determined of variable gene and the adjacent 5'- and 3'-sites of kappa-immunoglobulin light chain. Transversion C .fwdarw. G was found in the connective fragment J. This transversion is probably, a result of somatic mutation. Computer-assisted analysis was used to show the presence of deca- sites and their motifs in the sequence. Possible mechanisms of the participation of dc and pd sites in the regulation of the transcription of immunoglobulin genes were discussed.