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Onset of action and duration of effect of formoterol and salmeterol compared to salbutamol in isolated guinea pig trachea with or without epithelium



Onset of action and duration of effect of formoterol and salmeterol compared to salbutamol in isolated guinea pig trachea with or without epithelium



Allergy 47(4 Part 2): 384-387



Formoterol and salmeterol are 2 newly developed .beta.2-adrenoceptor agonists for inhalation with prolonged duration of effect compared with currently available .beta.2-agonists. The clincial duration of effect has been suggested to be correlated to decreased washability in vitro, i.e. decreased effect due to continuous washing of the organ bath. In this study we compared the washability and the onset of the relaxatory effect of formoterol (0.01 .mu.M), salmeterol (0.05 .mu.M) and salbutamol (0.1 .mu.M) in isolated guinea pig trachea contracted with carbachol (0.1 .mu.M). We also evaluated a possible influence of the epithelium on set of action and/or duration effect. A significant relaxatory effect of formoterol and salmeterol remained after washing, whereas no effect of salbutamol remained. We also found a rapid onset of action for both salbutamol and formoterol, but a significantly slower onset for salmeterol. Both the washability and the onset of action were found to be independent of the presence of the epithelium.

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Accession: 007617241

Download citation: RISBibTeXText

PMID: 1360770

DOI: 10.1111/j.1398-9995.1992.tb02076.x


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