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Optimal input design: case study of the metabolic process



Optimal input design: case study of the metabolic process



Mathematical Biosciences 97(2): 179-198



An optimal input of nutrients into the metabolic process of the individual subject so as to effect desired therapeutic results is particularly important for the critically ill. A patient-related, individualized nutrients optimization procedure is proposed here. The procedure is applicable to any time-invariant and deterministic metabolic model that is bound by one or more quantitative limiting criteria. As a case in hand, the procedure is used to optimize the individual metabolic needs of critically ill patients. The results indicate that, given a proper metabolic model, the patient may be treated on an individual appropriateness basis rather than on the traditional statistical intuitive approach.

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Accession: 007619468

Download citation: RISBibTeXText

PMID: 2520210

DOI: 10.1016/0025-5564(89)90004-7


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