EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism



Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism



American Journal of Physiology 263(1 Pt 2): H208-H217



We tested whether digoxin would limit tissue hypoxia during severe anemia by improving peripheral O2 distribution or decreasing O2 demands. Hematocrit (Hct) was reduced in eight control and eight digoxin-treated pigs from 27-28% to 17-18, 11-12, and 7-8%. Whole body and hindlimb blood flow, O2 transport, O2 extraction, and O2 consumption and serum catecholamines (epinephrine and norepinephrine) were determined at each Hct. Arterial and femoral venous lactate and O2 deficit were obtained to reflect tissue hypoxia. Cardiac output was significantly greater (P less than 0.05) with digoxin, as expected, but there were no differences in hindlimb blood flow. Also, whole body and hindlimb O2 extractions were equal in both groups for similar levels of O2 transport, suggesting that digoxin did not alter the relationship of O2 flow to metabolism in regional circulations. As whole body O2 consumption fell, controls accumulated more (P less than 0.05) O2 deficit and arterial lactate than the digoxin group. Furthermore, the slope demonstrating the linear increase of lactate with respect to O2 deficit was much steeper in controls (y = 1.11 + 0.06x) than in digoxin (y = 1.36 + 0.02x), suggesting that there were differences in the degree of tissue hypoxia for comparable O2 deficit. This may be attributed to the marked differences in catecholamine response: epinephrine was higher in controls at Hct of 7-8% and norepinephrine was higher at Hcts of 11-12 and 7-8%. Digoxin may have inhibited the release of catecholamine or reduced the stimulus for catecholamine secretion during anemia. We speculate that digoxin markedly improved the balance between peripheral O2 supply and demand during anemia by inhibiting catecholamine thermogenesis, thereby decreasing O2 demands. This may explain some of the salutary effects of glycosides in high-output cardiac failure with normal ventricular function.

(PDF emailed within 1 workday: $29.90)

Accession: 007627668

Download citation: RISBibTeXText

PMID: 1636760



Related references

Effect of digoxin on oxygen transport during anemic hypoxia. Pediatric Research 25(4 PART 2): 31A, 1989

Effects of acid and base infusions on oxygen transport during hypoxic anemic and stagnant hypoxia. Physiologist 25(2): 88-89, 1982

The assessment of blood gas transport by red cell affinity to oxygen in acute and chronic anemic hypoxia. Gematologiya i Transfuziologiya 40(1): 30-32, 1995

The external respiratory reaction and its significance for oxygen transport in rats in acute anemic hypoxia. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 76(5): 668-677, 1990

External respiration response and its significance for oxygen transport in conditions of acute anemic hypoxia in rats. Fiziologicheskii Zhurnal SSSR Imeni I M Sechenova 76(5): 668-677, 1990

Evaluation of blood gas transport function according to the degree of oxygen affinity of erythrocytes in acute and chronic anemic hypoxia. Gematologiia i Transfuziologiia 40(1): 30-32, 1995

Effect of anemic- and hypoxic-hypoxia on cerebral oxygen metabolism studying with microscopic reflectance spectroscopy. Japanese Journal of Physiology 42(SUPPL ): S63, 1992

Effects of short-term hypoxia on metabolism and haemocyanin oxygen transport in the prawns Palaemon adspersus and Palaemonetes varians. Marine Ecology Progress Series 167(0): 177-183, June 18, 1998

Maximal oxygen consumption during anemic hypoxia vs hypoxic hypoxia in canine gastrocnemius in situ. Medicine & Science in Sports & Exercise 22(2 SUPPL): S70, 1990

Effects of perflubron emulsion on oxygen transport in the anemic anesthetized dog. Hogan, M C, Mathieu-Costello, O, Poole, D C, Wagner, P D Advances in Experimental Medicine and Biology; Oxygen transport to tissue XVI 383, 1994

Relationship between mixed venous oxygen saturation and markers of tissue oxygenation in progressive hypoxic hypoxia and in isovolemic anemic hypoxia in 8- to 12-day-old piglets. Critical Care Medicine 27(9): 1885-1892, 1999

Effect of oxygen therapy on the oxygen supply during anemic hypoxia caused by fatal hemodilution. Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia: 50-53, 1981

Dependence of skeletal muscle oxygen consumption on oxygen delivery during active contraction in chronic anemic hypoxia. American Review Of Respiratory Disease Suppl: A201, 1986

The effects of acute induced hypoxia on coronary circulation Hypoxia and cardiac oxygen metabolism. Japanese Circulation Jour: 212, 1960

Effects of Hypoxia and Hypercapnic Hypoxia on Oxygen Transport and Acid-Base Status in the Atlantic Blue Crab, Callinectes sapidus, During Exercise. Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology (): -, 2016