Percutaneous toxicity of ethylene glycol monomethyl ether and of dipropylene glycol monomethyl ether in the rat

Fairhurst, S.; Knight, R.; Marrs, T.C.; Scawin, J.W.; Spurlock, M.S.; Swanston, D.W.

Toxicology 57(2): 209-215

1989


ISSN/ISBN: 0300-483X
PMID: 2749747
DOI: 10.1016/0300-483x(89)90166-2
Accession: 007640109

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Abstract
The subacute percutaneous toxicity of dipropylene glycol monomethyl ether (DPM) in male rats dosed 5 days/week for 4 weeks under both occluded and unoccluded conditions has been assessed and compared to the percutaneous toxicity of ethylene glycol monomethyl ether (EGM). DPM caused no significant changes in the clinical chemistry, haematology, or pathology, whereas EGM caused changes in the haematology and clinical chemistry, and both testicular and bone marrow damage at doses of 1000 mg/kg per day.