+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Pharmacokinetics in healthy volunteers and patients with impaired renal function after oral cefotiam hexetil



Pharmacokinetics in healthy volunteers and patients with impaired renal function after oral cefotiam hexetil



Acta Therapeutica 15(4): 337-354



We compared the absorption of cefotiam after oral administration in 11 adult male volunteers and 20 patients (16 males, 4 females) with various degrees of renal failure. Volunteers and patients received 400 mg of cefotiam hexetil (SCE-2174) as two tablets of 200 mg potency (calculated on the basis of cefotiam potency). Pharmacokinetic parameters were determined assuming a modified one compartment model. Mean values for maximum concentration of drug in serum, time to maximum concentration, elimination half-life and total area under the curve were about 4.9 mg/l, 58 min, 57 min, and 8.5 mg .cntdot. h/l, respectively, for the volunteers, and 8.8 mg/l, 116 min, 354 min, and 66 mg .cntdot. h/l for patients; the values are calculated for 0.2 g/70 kg. The mean renal clearance of cefotiam was 254 ml/min/1.73 m2 in volunteers and 23 ml/min/1.73 m2 in patients. We recovered 34% of the administered dose from the urine in the volunteers but only 14% in the patient group. In an earlier study, we had compared the pharmacokinetic parameters of cefotiam in both volunteers and patients after a single shot bolus injection of 1 g, and we used those results to calculate the relative bioavailability. We found no significant differences between normal subjects and patients in either bioavailability (51% and 49%) or volume of distribution (16.8 1/70 kg and 15.4 1/70 kg). However, marked differences were observed in both total clearance (377 vs. 56 ml/min/1.73 m2) and extrarenal clearance (123 vs. 33 ml/min/1.73 m2). We conclude that the pharmacokinetic parameters of cefotiam are influenced by the quality of renal function and that oral doses should be adjusted according to the severity of the renal impariment and the sensitivity of the bacteria involved.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 007646232

Download citation: RISBibTeXText


Related references

Pharmacokinetics of oral cefcanel daloxate hydrochloride in healthy volunteers and patients with various degrees of impaired renal function. Journal of Antimicrobial ChemoTherapy 33(2): 281-288, 1994

Skin tissue fluid levels of cefotiam in healthy man following oral cefotiam hexetil. European Journal of Clinical Pharmacology 39(1): 33-36, 1990

Pharmacokinetics of cefroxadine in healthy volunteers and patients with impaired renal function. ChemoTherapy 27(3): 149-154, 1981

Pharmacokinetics of netilmicin in healthy volunteers and patients with impaired renal function. Revista de Farmacologia Clinica y Experimental 3(1): 29-38, 1986

Biapenem pharmacokinetics in healthy volunteers and in patients with impaired renal function. Arzneimittel-Forschung 47(11): 1250-1256, 1997

Pharmacokinetics of ribostamycin in healthy volunteers and patients with impaired renal function. Japanese Journal of Antibiotics 33(12): 1318-1331, 1980

Effect of oral cefotiam hexetil sce 2174 on fecal bacteria in human volunteers. Microbial Ecology in Health & Disease 4(2): 89-94, 1991

Effect of Oral Cefotiam Hexetil (SCE2174) on Faecal Bacteria in Human Volunteers. Microbial Ecology in Health and Disease 4(2): 89-94, 1991

Pharmacokinetics of a single oral dose of Prajmalium bitartrate on patients with impaired liver function compared to healthy volunteers. Naunyn-Schmiedeberg's Archives of Pharmacology 349(Suppl. ): R143, 1994

Pharmacokinetics of cefotiam in patients with impaired renal function and in those undergoing hemodialysis. Antimicrobial Agents and ChemoTherapy 26(5): 647-651, 1984

Pharmacokinetics of cefotiam and cefsulodin after simultaneous administration to patients with impaired renal function. Antimicrobial Agents and ChemoTherapy 26(3): 368-372, 1984

Fleroxacin pharmacokinetics in healthy volunteers and impaired renal function. Journal of ChemoTherapy 1(4 Suppl): 558-560, 1989

Distribution of cefotiam in human lung tissue after multiple oral administration of cefotiam hexetil. European Journal Of Clinical Pharmacology. 46(4): 383-384, 1994

Pharmacokinetics of cefotiam iv in subjects with normal and impaired renal function. Acta Therapeutica 15(1): 3-16, 1989

Pharmacokinetics of ciprofloxacin in healthy volunteers and patients with impaired kidney function. Journal of Antimicrobial ChemoTherapy 18 Suppl D: 83-87, 1986