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Phenylisothiocyanate in heterocyclic synthesis novel synthesis of thiazoles thieno 2 3 b pyridine thiophene and thieno 3 2 c pyridazone derivatives



Phenylisothiocyanate in heterocyclic synthesis novel synthesis of thiazoles thieno 2 3 b pyridine thiophene and thieno 3 2 c pyridazone derivatives



Monatshefte fuer Chemie 123(4): 341-347



The enamino nitriles 1 and 2 react with phenyl isothiocyanate followed by cyclization with .alpha.-haloketones 3 and 10 to afford in each case the thiazole 5, thiophene 11 and the thieno[2,3-b]pyridine derivatives 19 and 21. Chemical and spectroscopic evidences for the structures of the new compounds are described.

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