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Polypeptides p40 pom2 and pangr are required for iron uptake and for virulence of the marine fish pathogen of vibrio anguillarum 775

Polypeptides p40 pom2 and pangr are required for iron uptake and for virulence of the marine fish pathogen of vibrio anguillarum 775

Journal of Bacteriology 173(3): 1347-1352

Insertions were created in three iron uptake genes in plasmid pJM1 of Vibrio anguillarum 775 to assess their in vivo effects on virulence in fish. Insertions that blocked p40, pOM2, and pAngR expression resulted in iron uptake-negative strains and in 4.2 .times. 105-, 8.8 .times. 105-, and 2.5 .times. 105-fold attenuations in virulence, respectively. A strain with an insertion in the pAngR coding region still synthesized significant constitutive levels of the outer membrane protein pOM2 and persisted in fish for at least 14 days postinjection. The results demonstrate a direct relationship between virulence and three pJM1-encoded gene products and also the feasibility of constructing live attenuated strains of V. anguillarum that might be useful in future vaccines.

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Accession: 007667076

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PMID: 1846864

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