Section 8
Chapter 7,688

Primary structures of cytotoxic factors isolated from habu (Trimeresurus flavoviridis) venom

Yamakawa, Y.; Omori-Satoh, T.; Maeyama, J.

Journal of Biochemistry 109(5): 667-669


ISSN/ISBN: 0021-924X
PMID: 1917887
Accession: 007687944

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The amino acid sequence of a cytotoxic factor, CTF-I, isolated from the venom of the Japanese habu snake (Trimeresurus flavoviridis) has been determined through automatic phenylisothiocyanate degradation of the PE-protein and derived proteolytic peptides. CTF-I consists of 72 amino acids and contains an Arg-Gly-Asp sequence present in trigramin-like peptides isolated from other snake venoms. The primary structure of another cytotoxic factor, CTF-II, consisting of 75 amino acids, was deduced to comprise that of CTF-1 with an additional Glu-Leu-Leu-sequence at its N-terminal.

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