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Protection against Marek's disease by a fowlpox virus recombinant expressing the glycoprotein B of Marek's disease virus

Nazerian, K.; Lee, L.F.; Yanagida, N.; Ogawa, R.

Journal of Virology 66(3): 1409-1413

1992


ISSN/ISBN: 0022-538X
PMID: 1310755
Accession: 007698897

Fowlpox virus (FPV) recombinants expressing the glycoprotein B and the phosphorylated protein (pp38) of the GA strain of Marek's disease virus (MDV) were assayed for their ability to protect chickens against challenge with virulent MDV. The recombinant FPV expressing the glycoprotein B gene elicited neutralizing antibodies against MDV, significantly reduced the level of cell-associated viremia, and, similar to the conventional herpesvirus of turkeys, protected chickens against challenge with the GA strain and the highly virulent RB1B and Md5 strains of MDV. The recombinant FPV expressing the pp38 gene failed to either elicit neutralizing antibodies against MDV or protect the vaccinated chickens against challenge with MDV.

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