+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Quantitative ultrastructural studies of gall bladder epithelium in gall stone free subjects and patients with gall stones

Quantitative ultrastructural studies of gall bladder epithelium in gall stone free subjects and patients with gall stones

Gut 31(1): 100-105

The present study aimed at a further evaluation of the role of glycoproteins in the formation of cholesterol gall stones in man. An electron microscopic morphometric study of the gall bladder epithelium was performed in six gall stone free subjects and 12 gall stone patients. Six of the gall stone patients were treated with ursodeoxycholic acid three weeks before cholecystectomy. The number and the volume density of the mucin containing secretory granules, were not significantly increased in gall stone patients compared with gall stone free subjects. Treatment with ursodeoxycholic acid did not affect the number or volume density of the secretory granules. Thus, these results do not give evidence for that the degree of cholesterol saturation influences mucin content in the gall bladder wall of man. A major new finding was that gall stone patients had a markedly reduced total lysosome area and volume density of lysosomes compared with gall stone free subjects, a finding which may be related to a decreased intracellular degradation of protein and/or mucin.

(PDF emailed within 0-6 h: $19.90)

Accession: 007715510

Download citation: RISBibTeXText

PMID: 2318423

DOI: 10.1136/gut.31.1.100

Related references

Experimental studies in gall-stone formation IV A contribution to the knowledge of the etiology of gall-stone formation 1 Studies on the influence of the functions of the autonomic nervous system on gall-stone formation 2 Studies on the formation of bilirubin-calcium stones. 1928

Prognosis of gall bladder stone without symptoms in mass survey physical examination of old age and pathological autopsy and surgical indication on symptomless gall stone considering gall bladder cancer. Gastroenterologia Japonica 3(3): 169-170, 1968

Quantitative and qualitative comparison of gall bladder mucus glycoprotein from patients with and without gall stones. Gut 27(4): 374-381, 1986

A contribution to the etiology of gall stones. 3. A study of the hydrogen-ion concentration of gall bladder bile and its effect upon gall stones. Amer. J. Digest. Dis. Nutrit, 4: 223-225, 1937

Gall bladder emptying patterns in response to a normal meal in healthy subjects and patients with gall stones: ultrasound study. Gut 32(11): 1406-1411, 1991

Defective acid base regulation by the gall bladder epithelium and its significance for gall stone formation. Gut 37(1): 127-131, 1995

Gall bladder epithelium and cholesterol gall stones. Gut 31(12): 1423-1423, 1990

Effect of oral clarithromycin on gall-bladder motility in normal subjects and those with gall-stones. Alimentary Pharmacology & Therapeutics 24(1): 95-99, 2006

Gall stone disease without gall stones--bile acid and bile lipid metabolism after complete gall stone dissolution. Gut 27(5): 559-566, 1986

Studies on gall-stone composition. 4. Analysis of gall-stones by microchemical methods. Indian Journal of Medical Research 63(6): 810-817, 1975

Studies on gall stone composition part 4 analysis of gall stones by microchemical methods. Indian Journal of Medical Research 63(6): 810-817, 1975

The national cooperative gall stone study usa further therapy with chenodiol in patients who had partial dissolution of gall stones after 2 years. Gastroenterologypart 2: 1124, 1982

Can sincalide cholescintigraphy fulfil the role of a gall-bladder stress test for patients with gall-bladder stones?. Australian and New Zealand Journal of Surgery 68(7): 514-519, 1998

Postprandial gall-bladder emptying in patients with gall stones. British medical journal980 280(6208): 141-143, 1980

Gall-bladder sensitivity to cholecystokinin in patients with gall stones. British Medical Journal 280(6208): 143-144, 1980