Recovery of the rat vaginal epithelium from the histological effects of absorption enhancers

Richardson, J.L.; Thomas, N.W.; Illum, L.

International Journal of Pharmaceutics 77(1): 75-78

1991


ISSN/ISBN: 0378-5173
DOI: 10.1016/0378-5173(91)90304-7
Accession: 007727884

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Abstract
The recovery of the rat vaginal epithelium from the histological effects of absorption enhancers was assessed 24 h after treatment with laureth-9 and lysophosphatidylglycerol (LPG) solutions. In a control group of rats, the vaginal epithelium had a regular appearance and showed no sign of damage 24 h after administration of buffer solution. The vaginas treated with 0.5% LPG solution were similar to those of the control group although small sites showed reduced epithelial height were occasionally found. In contrast, 24 h after treatment with 1% laureth-9 solution, severe and widespread epithelial cell loss was evident with few signs of cellular regeneration and recovery. As previous studies have demonstrated absorption enhancing activity of both compounds, these results show that absorption enhancement is not necessarily linked with mucosal damage.