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Reduced insulin binding to liver plasma membrane and adipocyte of vacor rodenticide poisoned rats

Reduced insulin binding to liver plasma membrane and adipocyte of vacor rodenticide poisoned rats

Chonnam Journal of Medical Sciences 2(1): 21-25

Insulin binding to liver plasma membranes and adipocytes of 5 normal and 7 Vacor-poisoned rats has bene investigated to find extra-pancreatic factor responsible for Vacor-induced diabetes mellitus. Wistar rats were poisoned with low dose (5 mg/kg body weight) of Vacor to avoid an early death and yet to allow the development of glucose intolerance. Liver plasma membranes and adipocytes obtained from Vacor-poisoned rats at the 4th day after Vacor administration had a reduced insulin binding capacity as compared to normal ones. Scatchard analysis showed that the reduction of 125I-insulin binding in the Vacor-poisoned rats was due to a decrease in the number of insulin receptors in the membranes and adipocytes. These results suggest that Vacor-induced diabetes mellitus is at least in part due to the reduction in the number of insulin receptors in the peripheral tissues of Vacor-poisoned subjects.

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Accession: 007729636

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