EurekaMag
+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Top 15
A new species of the genus Haemogamasus from China (Acarina: Haemogamasidae)
Reference ranges for hematologic and serum biochemical values in llamas (Lama glama)
Slime mold beetles of the genus Anisotoma (Leiodidae): classification and evolution
To be young, gifted, black and female: a meditation on the cultural politics at play in representations of Venus and Serena Williams
Anti-drool cheiloplasty: clinical results in six dogs
Mentha taxonomic status as interpreted through cytology genetics and phytochemistry
Geomorphology of Lightning Creek valley, Manning Park, southwestern British Columbia
Algunos peces del Rio Autana
Development of a generic high-yield fed batch process for large-scale GMP manufacturing of human monoclonal antibodies
Treatment of 40 cases of paralysis of common peroneal nerve with acupuncture and moxibustion
Studies into the pigments in beetroot (Beta vulgaris L. ssp. vulgaris var. rubra L.)
Principles of the organization of therapeutic and preventive care in gynecologic diseases in children and adolescents
The assessment of binge eating severity among obese persons
Sample size requirements for evaluating a conservative therapy
Intensive production systems of fig (Ficus carica L.) under greenhouse conditions
+ Most Popular
Peptic ulcer and multiple papillomas of the esophagus and pylorus in an infant
Mind as a force field: comments on a new interactionistic hypothesis
Endothelin-1 plasma concentration in children and adolescents with atherogenic risk factors
Simple and rapid extraction method of total egg lipids for determining organochlorine pesticides in the egg
Management of grasslands for milk production and preservation of grass surplus
Primary duodenal tuberculosis diagnosed by endoscopic biopsy
Hypohydration and exercise: effects of heat acclimation, gender, and environment
Apropos of a Case of Esophageal Tuberculosis
Contributions to the knowledge of the Freshwater Entomostraca of South America, as shown by artificial hatching from dried material. Part i
Nutrient inputs to the Choptank River estuary: Implications for watershed management
Toxic metabolites of Amanita pantherina, A. cothurnata, A. muscaria and other Amanita species
Basic concepts and issues: a primer on distribution and sales representative agreements in the medical device and durable medical equipment industries
Recent changes in vaccination guidelines. An update on vaccines and target population initiatives
The results of research on the antioxidant emoksipin in clinical eye diseases
An overview of selected diseases and drug needs in the llama and alpaca industries
Hyperbaric oxygen therapy (HBOT) and peridontal health
Minimal Descriptors for Drumstick (Moringa oleifera Lam.) - An Underutilized Vegetable Crop
Demembrement du genre Cicindela L. (fin). V. Faune australienne. (Et liste recapitulative des genres et sous-genres proposes pour la faune mondiale)
Pollution of ground water by nutrients and fecal coliforms from lakeshore septic tank systems
Uber die Ausbruche von Maul- und Klauenseuche in den ersten 14 Tagen nach der aktiven Immunisierung mit Vakzine nach Waldmann und Kobe - Outbreaks of foot-and-mouth disease in the first 14 days after
Patologie delle alte vie respiratorie del bambino in ambulatorio: un'esperienza italiana. Diseases of the upper respiratory tract in children in ambulatory care: an Italian experience
Fundamentals of the scoliosis problem for the general practitioner
Estimating the time and temperature relationship for causation of deep-partial thickness skin burns
Containing costs in the ED
Precipitation of whey proteins concentrated by ultrafiltration

Resistance of metastatic pancreatic endocrine tumours after long-term treatment with the somatostatin analogue octreotide (SMS 201-995)


Resistance of metastatic pancreatic endocrine tumours after long-term treatment with the somatostatin analogue octreotide (SMS 201-995)



Clinical Endocrinology 30(4): 385-388



ISSN/ISBN: 0300-0664

PMID: 2557179

DOI: 10.1111/j.1365-2265.1989.tb00436.x

Ten patients with metastatic pancreatic endocrine tumours were treated with the long-acting somatostatin analogue octreotide (SMS 201-995). Three patients showed no response, clinically or biochemically, and treatment was therefore withdrawn. The seven remaining patients continued treatment for a median period of 28 months (range 13-54 months). Treatment was initially effective, symptoms improved and the concentrations of tumour-related hormones were reduced. Worsening of symptoms and rising levels of tumour-related hormone concentrations occurred a median of 5 months (range 1-6 months) after the start of therapy and were initially reversed by increasing the dose of octreotide over a median of 10 months (range 6-16 months). However, after a median of 13 months (range 5-34 months) at the maximum dosage symptoms recurred and were no longer responsive to a further increase in dosage of octreotide or other therapeutic measures. All patients died within a period of 5 months once this resistant phase of their illness had been reached.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 007748998

Download citation: RISBibTeXText

Related references

Resistance of long term treatment of pancreatic endocrine tumors with the somatostatin analogue octreotide sms 201 995. Regulatory Peptides 22(4): 439, 1988

Development of resistance to a long-acting somatostatin analogue during treatment of two patients with metastatic endocrine pancreatic tumours. Acta Endocrinologica 119(4): 561-566, 1988

Remission of symptoms during long term treatment of metastatic pancreatic endocrine tumours with long acting somatostatin analogue. BMJ 292(6526): 981-982, 1986

Remission of symptom during long term treatment of metastatic pancreatic endocrine tumours with long acting somatostatin analogue. British Medical Journal (1857) 292(6526): 981-982, 1986

Development of resistance to a long-acting somatostatin analogue during treatment of two patients with metastatic endocrine pancreatic tumours. European Journal of Endocrinology 119(4): 561-566, 1988

Long term therapy with the somatostatin analogue octreotide for metastatic vip producing pancreatic tumor. Schweizerische Medizinische Wochenschrift 122(33): 1221-1222, 1992

Remission of symptoms during long term treatment of metastatic pancreatic endocrine tumours with long acting somatostatin analogue. British Medical Journal 292(6526): 981-982, 1986

Long-term treatment of metastatic medullary thyroid carcinoma with the somatostatin analogue octreotide. Clinical Endocrinology 33(2): 261-269, 1990

Effect of somatostatin analogue (octreotide) on blood flow to endocrine tumors metastatic to the liver: angiographic evaluation. Radiology 177(2): 549-553, 1990

Treatment of malignant endocrine pancreatic tumors with a new long-acting somatostatin analogue, SMS 201-995. Scandinavian Journal of Gastroenterology 23(4): 508-512, 1988

Treatment of patients with metastatic pancreatic and gastrointestinal tumours with the somatostatin analogue Sandostatin: a phase II study including endocrine effects. British Journal of Cancer 62(4): 627-630, 1990

Long term treatment of patients with endocrine gastrointestinal tumors with the somatostatin analogue sms 201 995. Scandinavian Journal of Gastroenterology Suppl 21(119): 230-237, 1986

Use of the long acting somatostatin analogue octreotide oc for localization and treatment of a metastatic glucagonoma. Clinical Research 39(1): 101A, 1991

Use of somatostatin and its long-acting analogue, octreotide, in the treatment of pancreatic diseases. Alimentary Pharmacology and Therapeutics 9(5): 581-583, 1995

Rat pancreas after long-term treatment with the somatostatin analogue octreotide. Experimental Physiology 80(6): 1031-1038, 1995