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Role of energy intake from non ethanol ingredients of diet for negating the effects of maternal chronic alcohol consumption



Role of energy intake from non ethanol ingredients of diet for negating the effects of maternal chronic alcohol consumption



Biochemical Archives 4(4): 449-452



In several studies of the fetal alcohol syndrome, whena liquid diet containing 36% of calories from ethanol, 18% calories from protien 35% calories from fat and 11% calories from carbohydrate was fed to rats during pregnancy, the consumption was reduced by about 50% compared to those fed an isocaloric control diet ad libitum. The number of pups per litter born to alcohol-fed rats decreased by about 50% compared to the controls. The daily intake of energy and several nutrients was far below th elevel recommended for normal gestation and was suggested to have a role on the effects attributed t alcohl consumption. In a recent study, due to a long adaptation period to a 36% ethanal diet containing a higher lelel of protein (25% of total calories) prior to gestation, rats consumed similar amounts of ethanol diet obtained daily the same amount of caloried, protein, fat, vitamins and minerals as the controls. In spite of this apparent nutritional adequacy, a marked increase in the percent resorptions per litter and a decrease of live fetuses per litter, litter weight and fetal weight were observed. It is likely that these effects are related to the energy intake from dietary ingredients other than alcohol. This conclusion is supported by the fact that rats fed a 26% ethanol diet during pregnancy yield same number of pups as controls with a similar body weight as in control pups. Rats fed the 26% ethanol diet also obtain the required nutrition during pergnancy, ingest an amount of alcohol similar to rats fed the 36% alcohol diet but consume relatively more calories from non-alcohol ingredients of diet.

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