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Roles of murine macrophages in the maintenance of natural killer nk cell activity i. ontogeny of macrophage function for maintaining nk cell activity and an intrinsic macrophage defect in c3h hej mice



Roles of murine macrophages in the maintenance of natural killer nk cell activity i. ontogeny of macrophage function for maintaining nk cell activity and an intrinsic macrophage defect in c3h hej mice



Memoirs of the Faculty of Science Kyoto University Series of Biology 13(1): 1-16



The possibility that macrophages of newborn mice regulate the expression of NK cell activity in a manner different from macrophages of adult mice was investigated in the modulation of NK activity by peritoneal macrophages (PM). PM of newborns, but not those of adults, augmented the NK activity of freshly prepared spleen lymphoid cells. After a 20-hr culture, the NK activity of spleen lymphoid cell preparation was abrogated. The addition of PM of newborns was effective in maintaining NK cell activity during the culture period, but PM from adults were ineffective unless stimulated by lipopolysaccharides (LPS). Unexpectedly PM from newborn C3H/HeJ mice, histocompatible to regular C3H/He mice and genetically defective in the responsiveness to LPS, were unable to maintain the NK cell activity. Since the NK activity of C3H/HeJ spleen lymphoid cells was maintained normally after coculture with PM from newborn C3H/He mice, there seemed to be an intrinsic defect in C3H/HeJ PM. NK activity of spleen cells of two-week-old mice was very low. No effective suppressor cells were detectable in the spleen cell population. These results suggest that any genes other than those involved in the major histocompatibility complex determine the ability to maintain NK activity, and the PM of newborns are in a semi-activated stage, endowed with the potential for recruiting the organization of host defense from other cells at an age still unable to induce the antigen specific immune response.

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