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Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis

Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis

American Journal of Pathology 134(5): 1087-1097

Tissue factor (TF), the primary cellular initiator of the coagulation protease cascade, is implicated in having important roles in hemostasis, thrombogenesis, inflammation, and the cellular immune response, although the cytologic distribution of TF in tissues has yet to be described. This study used epitope-defined monoclonal antibodies to human tissue factor for immunohistochemical localization of TF in normal human tissues. TF was selectively expressed in tissues and was associated with cells rather than extracellular matrix. It was anatomically sequestered from blood, being undetectable in endothelium and peripheral blood cells. TF was present in vascular adeventitia, organ capsules, epidermis, and mucosal epithelium. Most dermal and submmucosal fibroblasts were negative. Except for alveolar macrophages and possibly dendritic cells ofsome lymphoid follicles, tissues macrophages did not express TF; (expression was demonstrable in LPS stimulated monocytes). Cerebral cortex, renal glomeruli, and cardiac myocytes were additional sites of prominent TF expression. Based on the cellular distribution of TF, it is hypothesized that intravascular initiation of coagulation requires induced expression by intravascular cells, and that the normal distribution of TF representa a hemostatic "envelope" ready to activate coagulation when vascular integrity is disrupted.

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Accession: 007777186

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PMID: 2719077

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