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Selective increase of a subset of T cell receptor gamma delta T lymphocytes in the peripheral blood of patients with human immunodeficiency virus type 1 infection



Selective increase of a subset of T cell receptor gamma delta T lymphocytes in the peripheral blood of patients with human immunodeficiency virus type 1 infection



Journal of Infectious Diseases 165(5): 917-919



Increased proportions of the small lymphoid subset expression T cell receptor (TCR) .gamma.delta. occur in different infectious diseases, particularly in mycobacterial infections. In this study the two main subsets of TCR .gamma.delta.+ cells in peripheral blood mononuclear cells (PBMC) of 54 patients with human immunodeficiency virus type 1 infection were analyzed. These subsets were defined by indirect immunofluorescence techniques and FACS analysis using BB3 and A13 monoclonal antibodies, which specifically react with V.delta.2- and V.delta.1-encoded forms of TCR .gamma.delta. The proportion of BB3+(V.delta.2+) and A13+ (V.delta.1+) cells was analyzed in purified PBMC populations. Patients were stratified according to Walter Reed (WR) clinical stage. A sharp increase in percentage of A13+ (V.delta.1+) cells was observed in all stages of the disease. In addition, a strict correlation was found with stage of the disease and percentage of CD8+ PBMC. An inverse correlation was found with the proportion of CD4+ PBMC. An early (WR2) inversion of the V.delta.2-to-V.delta.1 ratio was consistently detected even before the inversion of the CD4-to-CD8 ratio.

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Accession: 007777680

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PMID: 1533237


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