Selective regulation of eosinophil degranulation by interleukin 1 beta

Baskar, P.; Pincus, S.H.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 199(2): 249-254

1992


ISSN/ISBN: 0037-9727
PMID: 1741416
Accession: 007778213

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Abstract
Recent evidence confirms that cytokines such as IL-1, IL-4, IL-5, and GM-CSF may enhance or inhibit eosinophil function. Functions that are susceptible to modulation include eosinophil-mediated antibody-dependent damage of helminthic parasites [Schistosoma mansoni], oxidative metabolism and degranulation. We have employed IgG and IgE-coated Sepharose beads to investigate selective modulation of IgG and IgE-mediated enzyme release by IL-1.beta. Both IgG and IgE-coated beads induced release of granular enzymes .beta.-glucuronidase and arylsulfatase. Enzyme release from IgG-stimulated eosinophils was inhibited by preincubation with IL-1.beta. (100 pg/ml, P .ltoreq. 0.05). In contrast, enzyme release by IgE-stimulated eosinophils was enhanced by IL-1.beta. (100 pg/ml, P .ltoreq. 0.05). These studies support the hypothesis that IL-1.beta. has specific selective actions on eosinophil function. Furthermore, these actions on particle-stimulated enzyme release suggest that IgG and IgE mediated processes in eosinophils are differentially regulated.