+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Seroepidemiological study of infection with West Nile virus in Karachi, Pakistan, in 1983 and 1985

Seroepidemiological study of infection with West Nile virus in Karachi, Pakistan, in 1983 and 1985

Journal of Medical Virology 26(3): 243-247

The prevalence of West Nile (WN) virus infection in Karachi, Pakistan, was unknown until 1982. It had been noticed that there were more than a few patients with encephalitides in Karachi, and it was supposed that Japanese encephalitis (JE) cases would be found among them. Therefore, a seroepidemiological study was conducted to define the prevalence of WN virus infection and the possible occurrence of JE virus infection in the Karachi area. Prevalences of haemagglutination inhibition (HI) and neutralization (NT) antibodies against WN virus were studied among 81 serum samples (in July, 33 samples; in September, 48) during 1983, and among 156 paired serum samples that were collected twice, in July and October of 1985. Nearly the same antibody-positive rates were obtained in July of both years (1983: HI 55%; 1985: HI 53%; NT 50%); the rates increased slightly during September/October (1983: HI 65%; 1985: HI 59%, NT 54%). Among 156 paired samples in 1985, 20 (13%) and 12 (8%) showed positive- or negative-antibody conversion between July and October. Two serum samples from each of 156 residents obtained in July had a significantly higher NT antibody titre against JE virus than against WN virus (in case 1, JE 1:80, WN less than 1:10; in case 2, JE 1:40, WN less than 1:10). This is the first report to show the prevalence of WN virus infection in Karachi, Pakistan.

(PDF emailed within 0-6 h: $19.90)

Accession: 007783817

Download citation: RISBibTeXText

PMID: 2849632

DOI: 10.1002/jmv.1890260304

Related references

A Tale of Two Flaviviruses: A Seroepidemiological Study of Dengue Virus and West Nile Virus Transmission in the Ouest and Sud-Est Departments of Haiti. American Journal of Tropical Medicine and Hygiene (): -, 2016

Seroepidemiological study of west nile virus and rift valley Fever virus in some of Mammalian species (herbivores) in northern Turkey. Journal of Arthropod-Borne Diseases 7(1): 90-93, 2013

Seroepidemiological studies of flavivirus infection among domestic animals in and around Karachi, state of Sind, Pakistan. Japanese Journal of Veterinary Research 38(2): 50, 1990

Studies on West Nile virus infection by means of fluorescent antibodies n Pathogenesis of West Nile virus infection in experimentally inoculated chicks. 1963

Studies on West Nile infection by means of fluorescent antibodies I Pathogenesis of West Nile virus infection in experimentally inoculated suckling mice. 1963

A new competitive ELISA detects West Nile virus infection using monoclonal antibodies against the precursor-membrane protein of West Nile virus. Journal of Virological Methods 188(1-2): 132-138, 2013

The natural history of West Nile virus infection presenting with West Nile virus meningoencephalitis in a man with a prolonged illness: a case report. Journal of Medical Case Reports 5(): 204-204, 2011

Measles vaccine expressing the secreted form of West Nile virus envelope glycoprotein induces protective immunity in squirrel monkeys, a new model of West Nile virus infection. Journal of Infectious Diseases 206(2): 212-219, 2012

Association of an Opioid Standard of Practice Intervention With Intravenous Opioid Exposure in Hospitalized Patients. JAMA Internal Medicine, 2018

Epidemiologic study of chronic hepatitis B virus infection in male volunteer blood donors in Karachi, Pakistan. Bmc Gastroenterology 5(): 26-26, 2005

Using high titer West Nile intravenous immunoglobulin from selected Israeli donors for treatment of West Nile virus infection. Bmc Infectious Diseases 9(): 18-18, 2009

West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis. Emerging Infectious Diseases 7(4): 714-721, 2001

Case-control study of risk factors associated with hepatitis C virus infection among pregnant women in hospitals of Karachi-Pakistan. Tropical Medicine & International Health 13(6): 754-761, 2008

Immunization of flavivirus West Nile recombinant envelope domain III protein induced specific immune response and protection against West Nile virus infection. Journal of Immunology 178(5): 2699-2705, 2007

Detection of west Nile and Japanese encephalitis viral genome sequences in cerebrospinal fluid from acute encephalitis cases in Karachi, Pakistan. Microbiology and Immunology 38(10): 827-830, 1994