Serum trace elements in patients with hepatic cirrhosis and liver cancer
Jiang H M.; Et Al
Zhongguo Zhongliu Linchuang 17(6): 348-350
The contents of Cu, Zn, Cd and Mn were determined in the sera from 92 patients with hepatic diseases, including 40 early hepatic cirrhosis, 32 advanced hepatic cirrhosis and 20 liver cancer. The concentrations of all 4 kinds of trace elements and the ratios of Cu/Zn and Cd/Zn in 3 groups of patients were obviously higher than those in normal persons (P < 0.01). The levels of Cu, Zn, Mn and Cd/Zn ratio were also found to be significantly different among the 3 groups of patients (P < 0.001). Using single factor correlativity analysis, the highly positive correlation was found between Cu and Zn, whereas the correlation between Mn and Zn, as well as Mn and Cu were highly negative. However, when the data were analyzed with multiple factor stepwise discriminating analysis, only 2 factors, Cu and Mn, were found to be related to the advancement of hepatic cirrhosis and liver cancer. That is, the levels of serum Cu were increased in patients with liver cancer, while the levels of serum Mn were declined in all 3 groups of patients.