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Simultaneous analytical determination of procaine penicillin g and benzathine penicillin g by second derivative spectrophotometry

Simultaneous analytical determination of procaine penicillin g and benzathine penicillin g by second derivative spectrophotometry

Analytical Letters 25(7): 1275-1288

A new method for determining the binary mixtures of procaine penicillin G and benzathine penicillin G using "zero-crossing" second derivative spectrophotometry is described. Calibration graphs were linear up to 8.80 10-5 M for procaine penicillin G and 4.40 10-5 M for benzathine penicillin G. The method was realized in ethanol/water medium (30 % v/v). A complete and exhaustive statistical analysis of the experimental data was realized to demonstrate the validity of method. The method was applied for determining procaine penicillin G and benzathine penicillin G synthetic mixtures with good results. The procedure does not require any separation step.

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Accession: 007794289

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