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Spectrophotometric determination of hydralazine hydrochloride oxprenolol hydrochloride and chlorthalidone in combination and for oxprenolol hydrochloride as single component dosage form



Spectrophotometric determination of hydralazine hydrochloride oxprenolol hydrochloride and chlorthalidone in combination and for oxprenolol hydrochloride as single component dosage form



Drug Development & Industrial Pharmacy 16(9): 1539-1554



Three component tablet assay and single component tablet assay are presented. The first is performed for hydralazine hydrochloride, oxprenolol hydrochloride and chlorthalidone existing in a ratio 2.5:8.1 respectively. Hydralazine is estimated through absorbance measurements at 314 nm, D1 at 315 nm or D2-at 316 nm. Modified Vierordts method-after absorbance correction from hydralazine hydrochloride interference and also D2 methods are applied for oxprenolol hydrochloride assay. Chlorthalidone, the minor component, is assayed after its extraction using D1 or D2 measured at 282 nm and 268-284 nm respectively. For single tablet assay, oxprenolol hydrochloride is assayed using Amax at 272 nm, D1-measurement at 252-274 nm and D2-measurement at 260-278 nm. The first method is suffering from systematic error corrected by the latter two methods.

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