EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

State dependent retention effects with xylazine rompun in passive avoidance conditioning



State dependent retention effects with xylazine rompun in passive avoidance conditioning



Psychobiology 20(2): 139-142



To determine whether xylazine (Rompun), an alpha-2 adrenergic receptor agonist with sedative/analgestic properties, influences memory processes, rats were trained in a passive-avoidance task either before or after receiving the drug. Experiment 1 found that subjects who had received a 3-cc/kg Rompun injection (IP) 60 sec before training showed impaired retention when tested 24 h later in a mismatched-drug condition. This impairment, however, was reversed in an identically trained group that received a second injection of the drug 60 sec before testing. Thus, the amnestic effects of pretraining injections of Rompun are due to induction of state-dependent retention (SDR). Experiment 2 was designed to determine whether SDR would occur with alternative drug-to-training intervals. Nine possible intervals were sampled, ranging from drug administration 90 sec pretraining to 30 min posttraining. No evidence of retrograde effects were obtained: under the conditions employed, the drug must be administered at least 60 sec prior to training for memory impairment to occur.

(PDF emailed within 1 workday: $29.90)

Accession: 007817108

Download citation: RISBibTeXText



Related references

Effects of alcohol on acquisition and retention of passive-avoidance conditioning in different mouse strains. Journal of Comparative and Physiological Psychology 84(2): 398-402, 1973

Comparative studies on respiratory and circulatory changes in cattle during casting by means of Rompun-Hypnodil and Rompun-Pentothal (xylazine-metomidate and xylazine-thiopental). Vergleichende Untersuchungen uber Atmungs und Kreislaufveranderungen beim medikamentellen Niederlegen des Rindes mittels Rompun Hypnodil und Rompun Pentothal: 89, 1977

Time-dependent effects of reserpine on retention of passive avoidance. Pharmacology, Biochemistry, and Behavior 8(2): 103-105, 1978

Effect of β-funaltrexamine on retention of passive-avoidance conditioning. Behavioral and Neural Biology 44(3): 499-502, 1985

Effect of b-funaltrexamine on retention of passive-avoidance conditioning. Behavioral and Neural Biology 44: 9-502, 1985

Effect of beta-funaltrexamine on retention of passive-avoidance conditioning. Behavioral and Neural Biology 44(3): 499-502, 1985

NMDA receptor antagonism with MK-801 impairs consolidation and reconsolidation of passive avoidance conditioning in adolescent rats: evidence for a state dependent reconsolidation effect. Neurobiology of Learning and Memory 101: 114-119, 2013

State-dependent effects of ethanol on active and passive avoidance learning. Psychopharmacologia 25(3): 238-261, 1972

The central amygdala is involved in conditioning but not in retention of active and passive shock avoidance in male rats. Behavioral & Neural Biology 59(2): 143-149, 1993

Effects of delta9-tetrahydrocannabinol on active avoidance acquisition and passive avoidance retention in rats with amygdaloid lesions. Pharmacology 13(4): 297-308, 1975

Effects of clozapine and sulpiride on morphine state-dependent memory in the step-down passive avoidance test. Pharmacology 79(3): 149-153, 2006

Effects of different doses of glucose and insulin on morphine state-dependent memory of passive avoidance in mice. Psychopharmacology 175(4): 457-462, 2004

The effects of adenosine receptor agonists and antagonists on morphine state-dependent memory of passive avoidance. Neurobiology of Learning & Memory 78(2): 390-405, September, 2002

Discrepancy between effects of milligram and nanogram doses of a COX-2 inhibitor (celecoxib) on morphine state-dependent memory of passive avoidance in mice. Brain Research Bulletin 67(6): 443-447, 2005

Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice. Behavioural Brain Research 166(1): 184-187, 2005