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Studies on antifungal agents 30. novel substituted 3 2 furanyl 3 1h imidazol 1 ylmethyl 2 methyl 5 phenyl or phenyloxymethyl isoxazolidines



Studies on antifungal agents 30. novel substituted 3 2 furanyl 3 1h imidazol 1 ylmethyl 2 methyl 5 phenyl or phenyloxymethyl isoxazolidines



European Journal of Medicinal Chemistry 24(6): 579-584



The synthesis of a novel class of antifungal agents, the 3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-phenyl(or phenyloxymethyl)isoxazolidines (10-15) is described. When tested in vitro, derivatives 10-15 exerted a potent antifungal activity against dermatophytes, but were less effective against fungi causing systemic infections. However, analogues 10 and 12 showed minimum inhibitory concentration (MIC) values of 2.0 .mu.g/ml against Aspergillus fumigatus.

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Accession: 007830976

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