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Studies on citrate metabolism in normal subjects and kidney stone patients

Studies on citrate metabolism in normal subjects and kidney stone patients

Mineral and Electrolyte Metabolism 15(5): 303-308

The study was carried out in order to investigate citrate metabolism (i.e. serum levels, filtered load, tubular reabsorption, total and fasting urinary excretion) in a large group of normal subjects (n = 39) and kidney stone patients (n = 45). We found that mean serum citrate levels and filtered loads were similar in the two groups studied. On the other hand, both the 24-hour urinary citrate and the fasting citrate/creatinine ratio were significantly reduced, whereas the mean tubular reabsorption of citrate appeared to be significantly increased in kidney stone patients in respect to control subjects. A good correlation was found between the fasting and the 24-hour citrate/creatinine ratio in both normal subjects (r = 0.84, p less than 0.001) and kidney stone patients (r = 0.89, p less than 0.001). Our data indicate that the kidney appears to be involved in the pathogenesis of hypocitraturia in kidney stone patients and that a substantial proportion of these patients show a reduced urinary excretion of citrate. Finally, the evaluation of the fasting citrate/creatinine ratio may replace the measurement of the substance on the basis of a 24-hour urine collection.

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Accession: 007831408

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PMID: 2811789

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