EurekaMag.com logo
+ Site Statistics
References:
54,215,046
Abstracts:
30,230,908
PMIDs:
28,215,208
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Studies on constituents of higher fungi of korea lxvii antitumor components of the basidiocarp of ganoderma lucidum



Studies on constituents of higher fungi of korea lxvii antitumor components of the basidiocarp of ganoderma lucidum



Korean Journal of Mycology 18(2): 58-69



In order to find physiologically active components from higher fungi, hot-water soluble components were extracted from the basidiocarps of Ganoderma lucidum. The extract was purified and separated by DEAE cellulose ion exchange chromatography and Sepharose CL-4B gel filtration method. The separated fractions were designated CR, IN, IA, GL and GH. Fraction GL showed the highest antitumor activity among the fractions and its moleuclar weight was found to be 47 KD. The tumor inhibition ratio of Fr. GL was 81% at the dose of peritoneal administration of 20 mg/kg/day for 10 days in mice. Chemical analysis of this fraction showed 82% polysaccharide, 8% protein and 0.9% hexosamine. The polysaccharide moiety consisted of 63% glucose, 27% galactose, 7% mannose and 3% fucose. Fraction IN was found to increase the amount of superoxide anion in activated macrophages to 1.6-fold and the number of plaques in hemolytic plaque assay to 6-fold, respectively. These results indicate that the antitumor activity was exerted through immunopotentiation, but not through direct cytotoxicity against the tumor.

(PDF emailed within 1 workday: $29.90)

Accession: 007831508

Download citation: RISBibTeXText



Related references

Studies on constituents of higher fungi of Korea (LXXVIII) antitumor components of fusion hybrids between Ganoderma lucidum and Coriolus versicolor. Seoul University Journal of Pharmaceutical Sciences 19(0): 1-29, 1994

Studies on constituents of higher fungi of korea lvi. general constituents and immunostimulation of ganoderma lucidum. Korean Journal of Mycology 14(2): 149-164, 1986

Studies on constituents of higher fungi of korea lxiv constituents of cultured and fused mycelia of ganoderma lucidum. Seoul University Journal of Pharmaceutical Sciences 15: 38-71, 1990

Studies on constituents of the higher fungi of korea liv antitumor components of favolus alveolaris. Archives of Pharmacal Research (Seoul) 11(3): 203-212, 1988

Studies on constituents of the higher Fungi of Korea: Antitumor components of the basidiocarps of Hypsizigus marmoreus. Yakhak Hoeji 37(5): 490-498, 1993

Studies on constituents of higher fungi of Korea: (LXXIII) Antitumor components of the cultured mycelia of Paxillus atrotomentosus. Korean Journal of Mycology 20(3): 240-251, 1992

Studies on constituents of the higher fungi of korea lxix antitumor components of the cultured mycelia of lentinus edodes. Seoul University Journal of Pharmaceutical Sciences 16: 66-96, 1991

Studies on constituents of higher fungi of korea lvii. comparison of various antitumor constituents of coriolus versicolor. Korean Journal of Mycology 16(3): 162-174, 1988

Studies on antitumor components of the cultured mycelia of interspecific protoplast fusant F-2 of Ganoderma lucidum and Ganoderma applanatum. Korean Journal of Mycology 20(4): 324-336, 1992

Studies on constituents of the higher fungi of korea xlvii antitumor constituents of the cultured mycelia of agaricus campestris. Korean Journal of Mycology 13(3): 131-139, 1985

Studies on constituents of the higher fungi of korea 41. an antitumor fraction from the culture filtrate of lentinus edodes dmc 7. Korean Journal of Mycology 12(4): 129-132, 1984

Studies on constituents of the higher fungi of korea lxvi components of auricularia polytricha. Seoul University Journal of Pharmaceutical Sciences 16: 34-65, 1991

Studies on the constituents of the higher fungi of korea 18. components of russula pseudodelica and microporus affinis. Korean Journal of Mycology 8(1): 13-20, 1980

Comparison of basidiocarp morphology and pure culture between ganoderma lucidum and ganoderma tropicum. Bulletin of Taiwan Forestry Research Institute New Series 6(4): 397-406, 1991

Studies on the constituents of the higher fungi of Korea (XII). Antineoplastic components of Coriolus versicolor Fr., Pleurotus ostreatus (Fr.) Kummer and Lentinus edodes (Berk.) Singer. Journal of Natural Products 42(6): 684, 1979