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Studies on fermentation of cephalosporin c by cephalosporium acremonium c 82 123

Studies on fermentation of cephalosporin c by cephalosporium acremonium c 82 123

Zhongguo Yiyao Gongye Zazhi 21(8): 373-374

The effects of thiourea on the cephalosporin C (CPC) biosynthesis and morphological differentiation of C. acremonium C-83-123 in complex medium were investigated. Thiourea as an organic sulfur-containing compound is neither a metabolic regulator nor a sulfur source for CPC production. On the other hand, C. acremonium C-82-123 was unable to grow in the medium containing more than 0.2% thiourea. Thiourea and CPC in culture broth formed 3-guanylthio-3-deacetoxycephalosporin C(G-DOCPC) by a chemical reaction. The higher the concentration of thiourea and/or CPC, the more the production of G-DOCPC. When the concentration of thiourea in complex medium was 0.1% the production of G-DOCPC was 26.5% (the production of CPC as 100%), and the titre of CPC was not decreased. The growth cycle of C. acremonium completed after 56 h cultivation. A correspondence between the amount of unicellular arthrospore and the production of CPC was observed. Differentiation of swollen hyphal fragments to unicellular arthrospores was accompanied with the synthesis of CPC. There were two unicellular arthrospores types: spherical and oval. The production of CPC was increased with the spherical type.

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