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Studies on superoxide dismutase and catalase activities in rat brains that were exposed to high oxygen tension following intratracheal administration of superoxide dismutase


Studies on superoxide dismutase and catalase activities in rat brains that were exposed to high oxygen tension following intratracheal administration of superoxide dismutase



Chung-Ang Journal of Medicine 13(3): 341-352



In the present study, the changes in the production of the superoxide radicals and the activities of superoxide dismutase (Superoxide: superoxide oxidoreductase, EC 1.15.1.1, SOD) and catalase (Hydrogen peroxide: hydrogen peroxide oxidoreductase, EC 1.11.1.6) in the rat brains that were exposed to 95% O2 or air following the intratracheal administration of SOD were investigated. The results were summarized as follows: 1. The activity of Cu, Zn-SOD in the brains of rats exposed to 95% O2 after SOD administration were two to twelve times higher than those of rats exposed to air after either SOD or saline administration. 2. The activities of Mn-SOD in the rats that were exposed to 95% O2 or air following SOD or saline administration were significally higher than those in the control group (p < 0.01, p < 0.15). 3. In the brains of rats treated with SOD, the production of superoxide radicals appeared to be negligible or very low in comparison with those in the control groups. The production of superoxide radicals in the rats brains that were exposed to 95% O2 after saline administration decreased sequentially. 4. Most of homogenates prepared from the brains of rats exposed to 95% O2 after SOD or saline administration showed the catalase activity similar to those in the control group. 5. The activity of catalase in the experimental group of SOD administration decreased at 30 min., 2 hr., 6 hr. and 1 day exposed to air in comparison with those of the control group (p < 0.01, p < 0.05). In conclusion, it seems likely that the intratracheal administration of SOD, on one hand, accelerates the activity of SOD in the brains of rats which were exposed to 95% O2 and it suppresses the production of superoxide radical. Accordingly the superoxide dismutase could protect the brain effectively from the harmful effects following the exposure to hyperoxic state.

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