Section 8
Chapter 7,834

Studies on the biological function of the nucleotide base of vitamin B12

Eberhard, G.; Schlayer, H.; Joseph, H.; Fridrich, E.; Utz, B.; Müller, O.

Biological Chemistry Hoppe-Seyler 369(10): 1091-1098


ISSN/ISBN: 0177-3593
PMID: 2907405
Accession: 007833925

Download citation:  

Studies on the coenzyme activity of some nucleotide base analogues of adenosylcobalamine in the dioldehydratase and methylmalonyl-CoA mutase systems resulted in fundamental differences: Contrary to dioldehydratase the coenzyme activity remains in the methylmalonyl-CoA mutase system when adenosylcobamides with a strongly modified nucleotide base are studied. The analogues give a good growth response with Escherichia coli. In the growth test with Lactobacillus leichmanii only the cobamides that do not have substituted nucleotide bases in the positions 2 or 3 of their imidazole ring are active.

PDF emailed within 1 workday: $29.90