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Studies on the synthesis of antiulcer agents. IV. Synthesis and antiulcer activity of dihydrobenzofuranone derivatives






Yakugaku Zasshi 109(4): 232-240

Studies on the synthesis of antiulcer agents. IV. Synthesis and antiulcer activity of dihydrobenzofuranone derivatives

The derivatives of 3-[3-oxospiro[benzofuran-2(3H),1'-cyclopropan]-5-yl]acrylic acid (8) were synthesized and tested for antiulcer activities. As a result, 1-[3-[3-oxospiro-[benzofuran-2(3H),1'-cyclopropan]-5-yl]-acryloyl]piperidine(3t) and 4-[3[3-oxospiro[benzofuran-2(3H),1'-cyclopropan]-5-yl]acryloyl]morpholine(3u) exhibited potent antinuclear activities.

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Accession: 007836636

PMID: 2760809

DOI: 10.1248/yakushi1947.109.4_232



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