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Studies on the synthesis of antiulcer agents. IV. Synthesis and antiulcer activity of dihydrobenzofuranone derivatives



Studies on the synthesis of antiulcer agents. IV. Synthesis and antiulcer activity of dihydrobenzofuranone derivatives



Yakugaku Zasshi 109(4): 232-240



The derivatives of 3-[3-oxospiro[benzofuran-2(3H),1'-cyclopropan]-5-yl]acrylic acid (8) were synthesized and tested for antiulcer activities. As a result, 1-[3-[3-oxospiro-[benzofuran-2(3H),1'-cyclopropan]-5-yl]-acryloyl]piperidine(3t) and 4-[3[3-oxospiro[benzofuran-2(3H),1'-cyclopropan]-5-yl]acryloyl]morpholine(3u) exhibited potent antinuclear activities.

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Accession: 007836636

Download citation: RISBibTeXText

PMID: 2760809

DOI: 10.1248/yakushi1947.109.4_232



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